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Mouse Anti-SCD Recombinant Antibody (CBXS-2698) (CBMAB-S5450-CQ)

This product is a mouse antibody that recognizes SCD. The antibody CBXS-2698 can be used for immunoassay techniques such as: ELISA, WB.
See all SCD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2698
Application
ELISA, WB

Basic Information

Immunogen
SCD (NP_005054.3, 1aa-100aa) partial recombinant protein with GST tag
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Stearoyl-CoA Desaturase
Introduction
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17.
Entrez Gene ID
6319
UniProt ID
O00767
Alternative Names
Stearoyl-CoA Desaturase; Fatty Acid Desaturase; Stearoyl-CoA Desaturase (Delta-9-Desaturase); Stearoyl-CoA Desaturase Opposite Strand; Acyl-CoA Desaturase; Delta(9)-Desaturase; EC 1.14.19.1; HSCD1;
Function
Stearoyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284).
Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284).
Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069).
Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity).
Plays an important role in body energy homeostasis (By similarity).
Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Biological Process
Biological Process monounsaturated fatty acid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Biological Process response to fatty acidManual Assertion Based On ExperimentIBA:GO_Central
Biological Process unsaturated fatty acid biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-72
Helical: 73-93
Lumenal: 94-97
Helical: 98-118
Cytoplasmic: 119-217
Helical: 218-237
Lumenal: 238-241
Helical: 242-263
Cytoplasmic: 264-359
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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