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Mouse Anti-SCG2 Recombinant Antibody (6B7) (CBMAB-A7911-LY)

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Datasheet
SDS
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Basic Information

Host Animal
Mouse
Clone
6B7
Application
ELISA
Immunogen
SCG2 (NP_003460, 508 a.a. ~ 617 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
secretogranin II (chromogranin C)
Introduction
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq]
Entrez Gene ID
7857
UniProt ID
P13521
Alternative Names
CHGC; SN; SgII
Function
Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
Biological Process
Biological Process angiogenesisManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process endothelial cell migrationManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process eosinophil chemotaxisManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process induction of positive chemotaxisManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process MAPK cascadeManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process protein secretionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Neuroendocrine and endocrine secretory granules.
PTM
O-glycosylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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