SCG2

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq]

Full Name

secretogranin II (chromogranin C)

Function

Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.

Biological Process

Biological Process angiogenesisManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process endothelial cell migrationManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process eosinophil chemotaxisManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process induction of positive chemotaxisManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process MAPK cascadeManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process negative regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process protein secretionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted
Neuroendocrine and endocrine secretory granules.

PTM

O-glycosylated.