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Mouse Anti-SEC13 Recombinant Antibody (1G7) (CBMAB-A7952-LY)

The product is antibody recognizes SEC13. The antibody 1G7 immunoassay techniques such as: IF, ELISA.
See all SEC13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G7
Antibody Isotype
IgG2a, κ
Application
IF, ELISA

Basic Information

Immunogen
SEC13 (NP_109598, 226 a.a. ~ 324 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SEC13 homolog (S. cerevisiae)
Introduction
The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq]
Entrez Gene ID
6396
UniProt ID
P55735
Alternative Names
D3S1231E; SEC13L1; SEC13R; npp-20
Function
Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206).
Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity).
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).
It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
Biological Process
Biological Process COPII-coated vesicle buddingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transport1 PublicationNAS:UniProtKB
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of TORC1 signaling1 PublicationIC:ComplexPortal
Biological Process nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of TORC1 signaling1 PublicationIC:ComplexPortal
Biological Process protein exit from endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasmic vesicle, COPII-coated vesicle membrane
Endoplasmic reticulum membrane
Nucleus, nuclear pore complex
Lysosome membrane
In interphase, localizes at both sides of the NPC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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