Mouse Anti-SEC13 Recombinant Antibody (CBXS-0178) (CBMAB-S3164-CQ)

Name: Mouse Anti-SEC13 Recombinant Antibody (CBXS-0178)
SKU: CBMAB-S3164-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-0178

Application

IP, S-ELISA, ELISA

Immunogen

SEC13 (NP_109598, 226 a.a.-324 a.a) partial recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SEC13 homolog (S. cerevisiae)

Introduction

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found.

Entrez Gene ID

6396

UniProt ID

P55735

Alternative Names

SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component; GATOR Complex Protein SEC13; SEC13-Related Protein; SEC13-Like Protein 1; D3S1231E; SEC13L1; SEC13R; SEC13 Homolog, Nuclear Pore And COPII Coating Complex Component;

Function

Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206).
Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity).
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).
It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).

Biological Process

Biological Process COPII-coated vesicle buddingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transport1 PublicationNAS:UniProtKB
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of TORC1 signaling1 PublicationIC:ComplexPortal
Biological Process nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of TORC1 signaling1 PublicationIC:ComplexPortal
Biological Process protein exit from endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasmic vesicle, COPII-coated vesicle membrane
Endoplasmic reticulum membrane
Nucleus, nuclear pore complex
Lysosome membrane
In interphase, localizes at both sides of the NPC.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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