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Rabbit Anti-SEC13 Recombinant Antibody (CBXS-3680) (CBMAB-S0216-CQ)

This product is a rabbit antibody that recognizes SEC13. The antibody CBXS-3680 can be used for immunoassay techniques such as: WB.
See all SEC13 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXS-3680
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
RhSEC13 aa123-322
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SEC13 homolog (S. cerevisiae)
Introduction
The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found.
Entrez Gene ID
Human6396
Mouse110379
Rat297522
UniProt ID
HumanP55735
MouseQ9D1M0
RatQ5XFW8
Alternative Names
SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component; GATOR Complex Protein SEC13; SEC13-Related Protein; SEC13-Like Protein 1; D3S1231E; SEC13L1; SEC13R; SEC13 Homolog, Nuclear Pore And COPII Coating Complex Component;
Function
Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206).
Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity).
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).
It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
Biological Process
Biological Process COPII-coated vesicle buddingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transport1 PublicationNAS:UniProtKB
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of TORC1 signaling1 PublicationIC:ComplexPortal
Biological Process nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIMP:SGD
Biological Process positive regulation of TORC1 signaling1 PublicationIC:ComplexPortal
Biological Process protein exit from endoplasmic reticulumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasmic vesicle, COPII-coated vesicle membrane
Endoplasmic reticulum membrane
Nucleus, nuclear pore complex
Lysosome membrane
In interphase, localizes at both sides of the NPC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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