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Mouse Anti-SECISBP2 Recombinant Antibody (3A7) (CBMAB-A7960-LY)

The product is antibody recognizes SECISBP2. The antibody 3A7 immunoassay techniques such as: WB, ELISA.
See all SECISBP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A7
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SECISBP2 (NP_076982.3, 106 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SECIS binding protein 2
Introduction
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. [provided by RefSeq]
Entrez Gene ID
79048
UniProt ID
Q96T21
Alternative Names
DKFZp686C09169; SBP2
Function
Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
Biological Process
Biological Process forebrain neuron developmentIEA:Ensembl
Biological Process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEA:Ensembl
Biological Process selenocysteine incorporationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process striatum developmentIEA:Ensembl
Cellular Location
Isoform 1
Nucleus
Isoform 2
Mitochondrion
Involvement in disease
Thyroid hormone metabolism, abnormal (THMA):
A disorder associated with a reduction in type II iodothyronine deiodinase activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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