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SECISBP2

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. [provided by RefSeq]

Full Name

SECIS binding protein 2

Function

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

Biological Process

Biological Process forebrain neuron developmentIEA:Ensembl
Biological Process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEA:Ensembl
Biological Process selenocysteine incorporationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process striatum developmentIEA:Ensembl

Cellular Location

Isoform 1
Nucleus
Isoform 2
Mitochondrion

Involvement in disease

Thyroid hormone metabolism, abnormal (THMA):
A disorder associated with a reduction in type II iodothyronine deiodinase activity.

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Anti-SECISBP2 antibodies

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Mouse Anti-SECISBP2 Recombinant Antibody (3A7) (CBMAB-A7960-LY)

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Target: SECISBP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3A7

Application*: WB, E

Mouse Anti-SECISBP2 Recombinant Antibody (3A7)

Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-3008) (CBMAB-S5754-CQ)

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Target: SECISBP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3008

Application*: E, WB

Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-3008)

Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-0186) (CBMAB-S3172-CQ)

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Target: SECISBP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-0186

Application*: WB

Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-0186)

Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-4313) (CBMAB-S1558-CQ)

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Target: SECISBP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4313

Application*: DB, WB

Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-4313)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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