SECISBP2

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. [provided by RefSeq]
Full Name
SECIS binding protein 2
Function
Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
Biological Process
Biological Process forebrain neuron developmentIEA:Ensembl
Biological Process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEA:Ensembl
Biological Process selenocysteine incorporationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process striatum developmentIEA:Ensembl
Cellular Location
Isoform 1
Nucleus
Isoform 2
Mitochondrion
Involvement in disease
Thyroid hormone metabolism, abnormal (THMA):
A disorder associated with a reduction in type II iodothyronine deiodinase activity.
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Anti-SECISBP2 antibodies

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Mouse Anti-SECISBP2 Recombinant Antibody (3A7) (CBMAB-A7960-LY)

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Target: SECISBP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3A7
Application*: WB, E
Datasheet SDS

Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-3008) (CBMAB-S5754-CQ)

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Target: SECISBP2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3008
Application*: E, WB
Datasheet SDS

Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-0186) (CBMAB-S3172-CQ)

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Target: SECISBP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0186
Application*: WB
Datasheet SDS

Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-4313) (CBMAB-S1558-CQ)

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Target: SECISBP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4313
Application*: DB, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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