SECISBP2

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. [provided by RefSeq]

SECIS binding protein 2

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

Biological Process forebrain neuron developmentIEA:Ensembl
Biological Process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEA:Ensembl
Biological Process selenocysteine incorporationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process striatum developmentIEA:Ensembl

Isoform 1
Nucleus
Isoform 2
Mitochondrion

Thyroid hormone metabolism, abnormal (THMA):
A disorder associated with a reduction in type II iodothyronine deiodinase activity.