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Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-3008) (CBMAB-S5754-CQ)

This product is a mouse antibody that recognizes SECISBP2. The antibody CBXS-3008 can be used for immunoassay techniques such as: ELISA, WB.
See all SECISBP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3008
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa106-206 from human SECISBP2 (NP_076982) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SECIS binding protein 2
Introduction
The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
SECIS Binding Protein 2; Sec Insertion Sequence-Binding Protein 2; SBP2; Selenocysteine Insertion Sequence-Binding Protein 2; SECIS-Binding Protein 2;
Function
Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
Biological Process
Biological Process forebrain neuron developmentIEA:Ensembl
Biological Process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEA:Ensembl
Biological Process selenocysteine incorporationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process striatum developmentIEA:Ensembl
Cellular Location
Isoform 1
Nucleus
Isoform 2
Mitochondrion
Involvement in disease
Thyroid hormone metabolism, abnormal (THMA):
A disorder associated with a reduction in type II iodothyronine deiodinase activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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