Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-3008) (CBMAB-S5754-CQ)

Name: Mouse Anti-SECISBP2 Recombinant Antibody (CBXS-3008)
SKU: CBMAB-S5754-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-3008

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa106-206 from human SECISBP2 (NP_076982) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SECIS binding protein 2

Introduction

The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene.

Entrez Gene ID

79048

UniProt ID

Q96T21

Alternative Names

SECIS Binding Protein 2; Sec Insertion Sequence-Binding Protein 2; SBP2; Selenocysteine Insertion Sequence-Binding Protein 2; SECIS-Binding Protein 2;

Function

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

Biological Process

Biological Process forebrain neuron developmentIEA:Ensembl
Biological Process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEA:Ensembl
Biological Process selenocysteine incorporationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process striatum developmentIEA:Ensembl

Cellular Location

Isoform 1
Nucleus
Isoform 2
Mitochondrion

Involvement in disease

Thyroid hormone metabolism, abnormal (THMA):
A disorder associated with a reduction in type II iodothyronine deiodinase activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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