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Mouse Anti-SEMA4C Recombinant Antibody (CBXS-1875) (CBMAB-S4671-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1875
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
NS0-derived recombinant human Semaphorin 4C, Ala21-Gly663 (predicted), Accession # Q9C0C4
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Semaphorin 4C
Introduction
SEMA4C (Succinate Dehydrogenase Complex Subunit D Pseudogene 5) is a Pseudogene.
Entrez Gene ID
54910
UniProt ID
Q9C0C4
Alternative Names
Semaphorin 4C; Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4C; M-Sema F; SEMAI; Semaphorin-4C; M-SEMA-F; KIAA1739; SEMACL1; SEMAF;
Function
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity).
Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
Biological Process
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell migration in hindbrainISS:UniProtKB
Biological Process cerebellum developmentIEA:Ensembl
Biological Process muscle cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural tube closureISS:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process semaphorin-plexin signaling pathwayISS:UniProtKB
Cellular Location
Postsynaptic density membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Topology
Extracellular: 21-663
Helical: 664-684
Cytoplasmic: 685-833
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For research use only. Not intended for any clinical use.

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