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Rat Anti-SEMA4C Recombinant Antibody (CBXS-1876) (CBMAB-S0131-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXS-1876
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
NS0-derived recombinant mouse Semaphorin 4C, Glu22-Gly664, Accession # Q64151
Specificity
Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Semaphorin 4C
Introduction
SEMA4C (Succinate Dehydrogenase Complex Subunit D Pseudogene 5) is a Pseudogene.
Entrez Gene ID
20353
UniProt ID
Q64151
Alternative Names
AI426163; M-Sema F; Semacl1; Semaf; Semai; sema I
Function
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity).
Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
Biological Process
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell migration in hindbrainISS:UniProtKB
Biological Process cerebellum developmentIEA:Ensembl
Biological Process muscle cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural tube closureISS:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process semaphorin-plexin signaling pathwayISS:UniProtKB
Cellular Location
Postsynaptic density membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Topology
Extracellular: 21-663
Helical: 664-684
Cytoplasmic: 685-833
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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