SEMA4C

SEMA4C (Succinate Dehydrogenase Complex Subunit D Pseudogene 5) is a Pseudogene.

Full Name

Semaphorin 4C

Function

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity).
Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

Biological Process

Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell migration in hindbrainISS:UniProtKB
Biological Process cerebellum developmentIEA:Ensembl
Biological Process muscle cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural tube closureISS:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process semaphorin-plexin signaling pathwayISS:UniProtKB

Cellular Location

Postsynaptic density membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane

Topology

Extracellular: 21-663
Helical: 664-684
Cytoplasmic: 685-833