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Rabbit Anti-SEMG1 Recombinant Antibody (CBXS-1497) (CBMAB-S4350-CQ)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
CBXS-1497
Application
WB, IHC-P, IF
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Semenogelin I
Introduction
The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20.
Entrez Gene ID
Human6406
Mouse53878
Rat25013
UniProt ID
HumanP04279
MouseQ8C1W4
RatQ6P6X2
Alternative Names
Semenogelin I; Cancer/Testis Antigen 103; Semen Coagulating Protein; SemG; SgI; Semenogelin-1; DJ172H20.2; SgI-29; CT103;
Function
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.
Biological Process
Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process coagulationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process inseminationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of calcium ion importManual Assertion Based On ExperimentIDA:CACAO
Biological Process negative regulation of flagellated sperm motilityManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of serine-type endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process sperm capacitationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
Transglutaminase substrate.
Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SEMG1 Recombinant Antibody (SGII 6B1/3) (CAT#: CBMAB-S0366-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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