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Mouse Anti-SEMG1 Recombinant Antibody (SGII 6B1/3) (CBMAB-S0366-CQ)

This product is a mouse antibody that recognizes SEMG1. The antibody SGII 6B1/3 can be used for immunoassay techniques such as: WB, FC, IHC, IF, IP, CyTOF.
See all SEMG1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
SGII 6B1/3
Antibody Isotype
IgG2b
Application
WB, FC, IHC, IF, IP, CyTOF

Basic Information

Immunogen
Peptide from rat SGII (C terminus of p18: KEENSRENPF)
Specificity
Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Semenogelin I
Introduction
The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.
Entrez Gene ID
25013
UniProt ID
Q6P6X2
Alternative Names
RATSVPIIA; SVPIIA; SVS2P; Svp1; Svs2; Svs2p2
Function
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.
Biological Process
Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process coagulationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process inseminationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of calcium ion importManual Assertion Based On ExperimentIDA:CACAO
Biological Process negative regulation of flagellated sperm motilityManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of serine-type endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process sperm capacitationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
PTM
Transglutaminase substrate.
Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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