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Mouse Anti-SERPINA3 Recombinant Antibody (3F5) (CBMAB-A7990-LY)

The product is antibody recognizes SERPINA3. The antibody 3F5 immunoassay techniques such as: sELISA, ELISA.
See all SERPINA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F5
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
SERPINA3 (AAH10530, 1 a.a. ~ 423 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Serpin Family A Member 3
Introduction
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq]
Entrez Gene ID
12
UniProt ID
P01011
Alternative Names
AACT; ACT; GIG24; GIG25; MGC88254
Function
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process inflammatory response1 PublicationNAS:UniProtKB
Biological Process maintenance of gastrointestinal epithelium1 PublicationNAS:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of lipid metabolic process1 PublicationNAS:UniProtKB
Cellular Location
Secreted
PTM
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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