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Rabbit Anti-SERPINE2 Recombinant Antibody (CBXS-1617) (CBMAB-S4466-CQ)


See all SERPINE2 antibodies
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Summary

Host Animal
Rabbit
Specificity
Rat, Human
Clone
CBXS-1617
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serpin Family E Member 2
Introduction
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human5270
Rat29366
UniProt ID
HumanP07093
RatP07092
Alternative Names
Serpin Family E Member 2; Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2; Peptidase Inhibitor 7; Protease Nexin I; Serpin E2; PI-7; PN-1; PI7; GDN;
Function
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cerebellar granular layer morphogenesisIEA:Ensembl
Biological Process detection of mechanical stimulus involved in sensory perceptionIEA:Ensembl
Biological Process innervationIEA:Ensembl
Biological Process long-term synaptic potentiationIEA:Ensembl
Biological Process mating plug formationIEA:Ensembl
Biological Process negative regulation of blood coagulationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of cell growthIEA:Ensembl
Biological Process negative regulation of cell population proliferationIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Biological Process negative regulation of plasminogen activationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of platelet aggregationBy SimilarityISS:BHF-UCL
Biological Process negative regulation of protein catabolic processIEA:Ensembl
Biological Process negative regulation of protein processing1 PublicationIC:BHF-UCL
Biological Process negative regulation of proteolysisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of smoothened signaling pathwayIEA:Ensembl
Biological Process negative regulation of sodium ion transportIEA:Ensembl
Biological Process platelet activationIEA:Ensembl
Biological Process positive regulation of astrocyte differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein catabolic processIEA:Ensembl
Biological Process regulation of cell migration1 PublicationNAS:UniProtKB
Biological Process regulation of synaptic transmission, glutamatergicIEA:Ensembl
Biological Process regulation of timing of cell differentiationIEA:Ensembl
Biological Process secretion by cellIEA:Ensembl
Biological Process secretory granule organizationIEA:Ensembl
Biological Process seminal vesicle epithelium developmentIEA:Ensembl
Cellular Location
Secreted, extracellular space
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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