SERPINE2

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Serpin Family E Member 2

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cerebellar granular layer morphogenesisIEA:Ensembl
Biological Process detection of mechanical stimulus involved in sensory perceptionIEA:Ensembl
Biological Process innervationIEA:Ensembl
Biological Process long-term synaptic potentiationIEA:Ensembl
Biological Process mating plug formationIEA:Ensembl
Biological Process negative regulation of blood coagulationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of cell growthIEA:Ensembl
Biological Process negative regulation of cell population proliferationIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Biological Process negative regulation of plasminogen activationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of platelet aggregationBy SimilarityISS:BHF-UCL
Biological Process negative regulation of protein catabolic processIEA:Ensembl
Biological Process negative regulation of protein processing1 PublicationIC:BHF-UCL
Biological Process negative regulation of proteolysisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of smoothened signaling pathwayIEA:Ensembl
Biological Process negative regulation of sodium ion transportIEA:Ensembl
Biological Process platelet activationIEA:Ensembl
Biological Process positive regulation of astrocyte differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein catabolic processIEA:Ensembl
Biological Process regulation of cell migration1 PublicationNAS:UniProtKB
Biological Process regulation of synaptic transmission, glutamatergicIEA:Ensembl
Biological Process regulation of timing of cell differentiationIEA:Ensembl
Biological Process secretion by cellIEA:Ensembl
Biological Process secretory granule organizationIEA:Ensembl
Biological Process seminal vesicle epithelium developmentIEA:Ensembl

Secreted, extracellular space