SERPINE2

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Full Name
Serpin Family E Member 2
Function
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cerebellar granular layer morphogenesisIEA:Ensembl
Biological Process detection of mechanical stimulus involved in sensory perceptionIEA:Ensembl
Biological Process innervationIEA:Ensembl
Biological Process long-term synaptic potentiationIEA:Ensembl
Biological Process mating plug formationIEA:Ensembl
Biological Process negative regulation of blood coagulationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of cell growthIEA:Ensembl
Biological Process negative regulation of cell population proliferationIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Biological Process negative regulation of plasminogen activationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of platelet aggregationBy SimilarityISS:BHF-UCL
Biological Process negative regulation of protein catabolic processIEA:Ensembl
Biological Process negative regulation of protein processing1 PublicationIC:BHF-UCL
Biological Process negative regulation of proteolysisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of smoothened signaling pathwayIEA:Ensembl
Biological Process negative regulation of sodium ion transportIEA:Ensembl
Biological Process platelet activationIEA:Ensembl
Biological Process positive regulation of astrocyte differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein catabolic processIEA:Ensembl
Biological Process regulation of cell migration1 PublicationNAS:UniProtKB
Biological Process regulation of synaptic transmission, glutamatergicIEA:Ensembl
Biological Process regulation of timing of cell differentiationIEA:Ensembl
Biological Process secretion by cellIEA:Ensembl
Biological Process secretory granule organizationIEA:Ensembl
Biological Process seminal vesicle epithelium developmentIEA:Ensembl
Cellular Location
Secreted, extracellular space
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Anti-SERPINE2 antibodies

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Mouse Anti-SERPINE2 Recombinant Antibody (CF393) (CBMAB-FT115LY)

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Target: SERPINE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF393
Application*: ELISA, WB
Datasheet SDS

Mouse Serpine2 ELISA Kit (V2LY-0626-LY5810)

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Target: Serpine2
Sensitivity: 0.00056 ng/mL
Detection Range: 0.001-0.4 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human SERPINE2 ELISA Kit (V2LY-0626-LY4613)

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Target: SERPINE2
Sensitivity: 0.052 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-SERPINE2 Recombinant Antibody (3G12) (CBMAB-A8005-LY)

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Target: SERPINE2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G12
Application*: WB, E
Datasheet SDS

Rat Anti-SERPINE2 Recombinant Antibody (CBXS-2568) (CBMAB-S5324-CQ)

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Target: SERPINE2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXS-2568
Application*: WB
Datasheet SDS

Mouse Anti-SERPINE2 Recombinant Antibody (CBXS-1830) (CBMAB-S4636-CQ)

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Target: SERPINE2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1830
Application*: WB
Datasheet SDS

Rat Anti-SERPINE2 Recombinant Antibody (CBXS-1722) (CBMAB-S4556-CQ)

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Target: SERPINE2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-1722
Application*: WB, IP
Datasheet SDS

Rabbit Anti-SERPINE2 Recombinant Antibody (CBXS-1617) (CBMAB-S4466-CQ)

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Target: SERPINE2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBXS-1617
Application*: WB
Datasheet SDS

Mouse Anti-SERPINE2 Recombinant Antibody (CBXS-0253) (CBMAB-S3230-CQ)

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Target: SERPINE2
Host: Mouse
Specificity: Human
Clone: CBXS-0253
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SERPINE2 Recombinant Antibody (CBXS-5225) (CBMAB-S2441-CQ)

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Target: SERPINE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5225
Application*: F, P, WB
Datasheet SDS

Mouse Anti-SERPINE2 Recombinant Antibody (CBXS-4765) (CBMAB-S1993-CQ)

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Target: SERPINE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4765
Application*: F, WB
Datasheet SDS

Mouse Anti-SERPINE2 Recombinant Antibody (CBXS-4469) (CBMAB-S1711-CQ)

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Target: SERPINE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4469
Application*: WB, F, IH, P
Datasheet SDS

Mouse Anti-SERPINE2 Recombinant Antibody (CBXS-4190) (CBMAB-S1443-CQ)

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Target: SERPINE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4190
Application*: WB
Datasheet SDS

Mouse Anti-SERPINE2 Recombinant Antibody (CBXS-4041) (CBMAB-S1302-CQ)

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Target: SERPINE2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4041
Application*: E, WB, IH, IF
Datasheet SDS

Rat Anti-SERPINE2 Recombinant Antibody (CBXS-3657) (CBMAB-S0936-CQ)

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Target: SERPINE2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXS-3657
Application*: WB
Datasheet SDS

Mouse Anti-SERPINE2 Recombinant Antibody (CBXS-5620) (CBMAB-S0498-CQ)

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Target: SERPINE2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-5620
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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