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Mouse Anti-SERPINF1 Recombinant Antibody (CBXS-3924) (CBMAB-S0165-CQ)

This product is a mouse antibody that recognizes SERPINF1. The antibody CBXS-3924 can be used for immunoassay techniques such as: WB, ELISA.
See all SERPINF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3924
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
Recombinant human PEDF (19-418 aa) purified from E. coli (NP_002606)
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.1% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serpin Family F Member 1
Introduction
This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI.
Entrez Gene ID
5176
UniProt ID
P36955
Alternative Names
Serpin Family F Member 1; Serine (Or Cysteine) Proteinase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1; Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1; Cell Proliferation-Inducing Gene 35 Protein; Pigment Epithelium-Derived Factor; EPC-1; PEDF; Testis Tissue Sperm-Binding Protein Li 70n;
Function
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Biological Process
Biological Process agingIEA:Ensembl
Biological Process cellular response to cobalt ionIEA:Ensembl
Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process cellular response to glucose stimulusIEA:Ensembl
Biological Process cellular response to retinoic acidIEA:Ensembl
Biological Process epithelial cell proliferation involved in prostate gland developmentIEA:Ensembl
Biological Process kidney developmentIEA:Ensembl
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of endothelial cell migrationIEA:Ensembl
Biological Process negative regulation of epithelial cell proliferation involved in prostate gland developmentIEA:Ensembl
Biological Process negative regulation of gene expressionIEA:Ensembl
Biological Process negative regulation of inflammatory responseIEA:Ensembl
Biological Process negative regulation of neuron deathIEA:Ensembl
Biological Process ovulation cycleIEA:Ensembl
Biological Process positive regulation of neurogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentIEA:Ensembl
Biological Process response to acidic pHIEA:Ensembl
Biological Process response to arsenic-containing substanceIEA:Ensembl
Biological Process response to peptideIEA:Ensembl
Biological Process retina development in camera-type eyeIEA:Ensembl
Biological Process short-term memoryIEA:Ensembl
Cellular Location
Secreted
Melanosome
Enriched in stage I melanosomes.
Involvement in disease
Osteogenesis imperfecta 6 (OI6):
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI6 is a severe, autosomal recessive form compatible with OI type III in the Sillence classification.
PTM
The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.
N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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