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Rabbit Anti-SERPINF1 Recombinant Antibody (BA0380) (CBMAB-0821CQ)

This product is a rabbit antibody that recognizes SERPINF1. The antibody BA0380 can be used for immunoassay techniques such as: WB, FC.
See all SERPINF1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
BA0380
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Immunogen
Synthetic peptide from Human PEDF aa 1-100
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serpin Family F Member 1
Introduction
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Entrez Gene ID
5176
UniProt ID
P36955
Alternative Names
OI6; OI12; PEDF; EPC-1; PIG35
Function
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Biological Process
Biological Process agingIEA:Ensembl
Biological Process cellular response to cobalt ionIEA:Ensembl
Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process cellular response to glucose stimulusIEA:Ensembl
Biological Process cellular response to retinoic acidIEA:Ensembl
Biological Process epithelial cell proliferation involved in prostate gland developmentIEA:Ensembl
Biological Process kidney developmentIEA:Ensembl
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of endothelial cell migrationIEA:Ensembl
Biological Process negative regulation of epithelial cell proliferation involved in prostate gland developmentIEA:Ensembl
Biological Process negative regulation of gene expressionIEA:Ensembl
Biological Process negative regulation of inflammatory responseIEA:Ensembl
Biological Process negative regulation of neuron deathIEA:Ensembl
Biological Process ovulation cycleIEA:Ensembl
Biological Process positive regulation of neurogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of neuron projection developmentIEA:Ensembl
Biological Process response to acidic pHIEA:Ensembl
Biological Process response to arsenic-containing substanceIEA:Ensembl
Biological Process response to peptideIEA:Ensembl
Biological Process retina development in camera-type eyeIEA:Ensembl
Biological Process short-term memoryIEA:Ensembl
Cellular Location
Secreted
Melanosome
Enriched in stage I melanosomes.
Involvement in disease
Osteogenesis imperfecta 6 (OI6):
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI6 is a severe, autosomal recessive form compatible with OI type III in the Sillence classification.
PTM
The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.
N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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