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Mouse Anti-SF1 Recombinant Antibody (2E12) (CBMAB-A8019-LY)

The product is antibody recognizes SF1. The antibody 2E12 immunoassay techniques such as: WB, ELISA.
See all SF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
2E12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SF1 (NP_004621, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
splicing factor 1
Entrez Gene ID
Human7536
Mouse22668
UniProt ID
HumanQ15637
MouseQ64213
Alternative Names
D11S636; ZFM1; ZNF162
Function
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Biological Process
Biological Process Leydig cell differentiationIEA:Ensembl
Biological Process male sex determinationIEA:Ensembl
Biological Process mRNA 3'-splice site recognitionManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process mRNA splicing, via spliceosome1 PublicationIC:HGNC-UCL
Biological Process negative regulation of smooth muscle cell proliferationIEA:Ensembl
Biological Process nuclear body organizationIEA:Ensembl
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of steroid biosynthetic processIEA:Ensembl
Biological Process spliceosomal complex assembly1 PublicationNAS:UniProtKB
Cellular Location
Nucleus
PTM
Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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