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Mouse Anti-SF1 Recombinant Antibody (CBXS-4525) (CBMAB-S1765-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4525
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IHC-P, IF

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
splicing factor 1
Introduction
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
7536
UniProt ID
Q15637
Alternative Names
Splicing Factor 1; Zinc Finger Protein 162; Mammalian Branch Point-Binding Protein; Zinc Finger Gene In MEN1 Locus; Transcription Factor ZFM1; ZNF162;
Function
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Biological Process
Biological Process Leydig cell differentiationIEA:Ensembl
Biological Process male sex determinationIEA:Ensembl
Biological Process mRNA 3'-splice site recognitionManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process mRNA splicing, via spliceosome1 PublicationIC:HGNC-UCL
Biological Process negative regulation of smooth muscle cell proliferationIEA:Ensembl
Biological Process nuclear body organizationIEA:Ensembl
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of steroid biosynthetic processIEA:Ensembl
Biological Process spliceosomal complex assembly1 PublicationNAS:UniProtKB
Cellular Location
Nucleus
PTM
Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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