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Mouse Anti-SGCD Recombinant Antibody (3G10) (CBMAB-A8054-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3G10
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SGCD (NP_000328.2, 114 a.a. ~ 189 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
Introduction
The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq]
Entrez Gene ID
6444
UniProt ID
Q92629
Alternative Names
35DAG; CMD1L; DAGD; MGC22567; SG-delta; SGCDP; SGD
Function
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Biological Process
Biological Process calcium ion homeostasisIEA:Ensembl
Biological Process calcium-mediated signalingIEA:Ensembl
Biological Process cardiac muscle cell contractionIEA:Ensembl
Biological Process cardiac muscle cell developmentIEA:Ensembl
Biological Process cardiac muscle tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process coronary vasculature morphogenesisIEA:Ensembl
Biological Process heart contractionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein-containing complex localizationIEA:Ensembl
Cellular Location
Cell membrane, sarcolemma
Cytoplasm, cytoskeleton
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal recessive 6 (LGMDR6):
An autosomal recessive degenerative myopathy initially affecting the proximal limb girdle musculature. Muscle from patients shows a complete loss of delta-sarcoglycan as well as of the others components of the sarcoglycan complex.
Cardiomyopathy, dilated 1L (CMD1L):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Topology
Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-289
PTM
Glycosylated.
Disulfide bonds are present.
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For research use only. Not intended for any clinical use.

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