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Mouse Anti-SGCD Recombinant Antibody (dSarc3/12C1) (CBMAB-D2235-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Sarcoglycan Delta (SGCD). The antibody can be used for immunoassay techniques, such as IHC-Fr.
See all SGCD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
dSarc3/12C1
Antibody Isotype
IgG2a
Application
IHC-Fr

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
Introduction
SGCD is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy.
Entrez Gene ID
6444
UniProt ID
Q92629
Alternative Names
Sarcoglycan Delta; Sarcoglycan, Delta (35kDa Dystrophin-Associated Glycoprotein); 35 KDa Dystrophin-Associated Glycoprotein; Delta-SG; 35DAG; Dystrophin Associated Glycoprotein, Delta Sarcoglycan; Placental Delta Sarcoglycan;
Function
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Biological Process
Biological Process calcium ion homeostasisIEA:Ensembl
Biological Process calcium-mediated signalingIEA:Ensembl
Biological Process cardiac muscle cell contractionIEA:Ensembl
Biological Process cardiac muscle cell developmentIEA:Ensembl
Biological Process cardiac muscle tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process coronary vasculature morphogenesisIEA:Ensembl
Biological Process heart contractionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein-containing complex localizationIEA:Ensembl
Cellular Location
Cell membrane, sarcolemma
Cytoplasm, cytoskeleton
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal recessive 6 (LGMDR6):
An autosomal recessive degenerative myopathy initially affecting the proximal limb girdle musculature. Muscle from patients shows a complete loss of delta-sarcoglycan as well as of the others components of the sarcoglycan complex.
Cardiomyopathy, dilated 1L (CMD1L):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Topology
Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-289
PTM
Glycosylated.
Disulfide bonds are present.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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