Mouse Anti-SGCD Recombinant Antibody (CBXS-0947) (CBMAB-S3860-CQ)

Name: Mouse Anti-SGCD Recombinant Antibody (CBXS-0947)
SKU: CBMAB-S3860-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-0947

Application

S-ELISA, WB, ELISA

Immunogen

SGCD (NP_000328.2, 114 a.a.-189 a.a) partial recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)

Introduction

The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Entrez Gene ID

6444

UniProt ID

Q92629

Alternative Names

Sarcoglycan Delta; Sarcoglycan, Delta (35kDa Dystrophin-Associated Glycoprotein); 35 KDa Dystrophin-Associated Glycoprotein; Delta-SG; 35DAG; Dystrophin Associated Glycoprotein, Delta Sarcoglycan; Placental Delta Sarcoglycan;

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Biological Process

Biological Process calcium ion homeostasisIEA:Ensembl
Biological Process calcium-mediated signalingIEA:Ensembl
Biological Process cardiac muscle cell contractionIEA:Ensembl
Biological Process cardiac muscle cell developmentIEA:Ensembl
Biological Process cardiac muscle tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process coronary vasculature morphogenesisIEA:Ensembl
Biological Process heart contractionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein-containing complex localizationIEA:Ensembl

Cellular Location

Cell membrane, sarcolemma
Cytoplasm, cytoskeleton

Involvement in disease

Muscular dystrophy, limb-girdle, autosomal recessive 6 (LGMDR6):
An autosomal recessive degenerative myopathy initially affecting the proximal limb girdle musculature. Muscle from patients shows a complete loss of delta-sarcoglycan as well as of the others components of the sarcoglycan complex.
Cardiomyopathy, dilated 1L (CMD1L):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Topology

Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-289

PTM

Glycosylated.
Disulfide bonds are present.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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