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Rabbit Anti-SGTA (Phosphorylated S305) Recombinant Antibody (D23E10) (PTM-CBMAB-0581LY)

This antibody is a recombiant antibody against SGTA. The antibody can be used for immunoassay techniques, such as WB, IP.
See all SGTA antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D23E10
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha
Introduction
This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human6449
Monkey64667
UniProt ID
HumanO43765
MonkeyO70593
Function
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892).
Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892).
Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373).
It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605).
Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484).
Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).
Biological Process
Negative regulation of ER-associated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ER-associated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Posttranslational protein targeting to endoplasmic reticulum membraneManual Assertion Based On ExperimentIBA:GO_Central
Tail-anchored membrane protein insertion into ER membraneManual Assertion Based On ExperimentIDA:UniProtKB
Ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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