Mouse Anti-SGTA Recombinant Antibody (CF394) (CBMAB-FT125LY)

Name: Mouse Anti-SGTA Recombinant Antibody (CF394)
SKU: CBMAB-FT125LY
Rating: 5 (1 reviews)

See all SGTA antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CF394

Application

ELISA, IF, WB, IHC

Immunogen

small glutamine-rich tetratricopeptide repeat (TPR) -containing, alpha

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha

Introduction

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

Entrez Gene ID

6449

UniProt ID

O43765

Alternative Names

SGT, SGT1

Function

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892).
Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892).
Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373).
It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605).
Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484).
Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).

Biological Process

Negative regulation of ER-associated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ER-associated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Posttranslational protein targeting to endoplasmic reticulum membraneManual Assertion Based On ExperimentIBA:GO_Central
Tail-anchored membrane protein insertion into ER membraneManual Assertion Based On ExperimentIDA:UniProtKB
Ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-SGTA Recombinant Antibody (CF394)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

SGTA Matched Antibody Pair (1090) (CAT#: APMAB-1090LY)

SGTA Matched Antibody Pair (1091) (CAT#: APMAB-1091LY)

Related Products

Mouse Anti-SGTA Recombinant Antibody (CBXS-0337) (CAT#: CBMAB-S3308-CQ)

SGTA Matched Antibody Pair (1090) (CAT#: APMAB-1090LY)

SGTA Matched Antibody Pair (1091) (CAT#: APMAB-1091LY)

Mouse Anti-SGTA Recombinant Antibody (CBXS-2888) (CAT#: CBMAB-S5637-CQ)

Mouse Anti-SGTA Recombinant Antibody (CBXS-3784) (CAT#: CBMAB-S1056-CQ)

Mouse Anti-SGTA Recombinant Antibody (CBXS-5201) (CAT#: CBMAB-S2418-CQ)

Rabbit Anti-SGTA (Phosphorylated S305) Recombinant Antibody (D23E10) (CAT#: PTM-CBMAB-0581LY)

Mouse Anti-SGTA Recombinant Antibody (CBXS-3331) (CAT#: CBMAB-S6068-CQ)

Mouse Anti-SGTA Recombinant Antibody (CBXS-4759) (CAT#: CBMAB-S1988-CQ)

Mouse Anti-SGTA Recombinant Antibody (2E11) (CAT#: CBMAB-A8072-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry