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SGTA

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]
Full Name
Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha
Function
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892).
Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892).
Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373).
It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605).
Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484).
Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).
Biological Process
Negative regulation of ER-associated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ER-associated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Posttranslational protein targeting to endoplasmic reticulum membraneManual Assertion Based On ExperimentIBA:GO_Central
Tail-anchored membrane protein insertion into ER membraneManual Assertion Based On ExperimentIDA:UniProtKB
Ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis.
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Anti-SGTA antibodies

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Mouse Anti-SGTA Recombinant Antibody (CF394) (CBMAB-FT125LY)

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Target: SGTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF394
Application*: ELISA, IF, WB, IHC
Datasheet SDS

Mouse Anti-SGTA Recombinant Antibody (2E11) (CBMAB-A8072-LY)

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Target: SGTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E11
Application*: WB, E
Datasheet SDS

Rabbit Anti-SGTA (Phosphorylated S305) Recombinant Antibody (D23E10) (PTM-CBMAB-0581LY)

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Target: SGTA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D23E10
Application*: WB, IP
Datasheet SDS

Mouse Anti-SGTA Recombinant Antibody (CBXS-3331) (CBMAB-S6068-CQ)

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Target: SGTA
Host: Mouse
Specificity: Mouse
Clone: CBXS-3331
Application*: E, WB
Datasheet SDS

Mouse Anti-SGTA Recombinant Antibody (CBXS-2888) (CBMAB-S5637-CQ)

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Target: SGTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: CBXS-2888
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-SGTA Recombinant Antibody (CBXS-0337) (CBMAB-S3308-CQ)

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Target: SGTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0337
Application*: WB
Datasheet SDS

Mouse Anti-SGTA Recombinant Antibody (CBXS-5201) (CBMAB-S2418-CQ)

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Target: SGTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXS-5201
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-SGTA Recombinant Antibody (CBXS-4759) (CBMAB-S1988-CQ)

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Target: SGTA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXS-4759
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-SGTA Recombinant Antibody (CBXS-3784) (CBMAB-S1056-CQ)

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Target: SGTA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3784
Application*: WB, F, E, IF
Datasheet SDS

SGTA Matched Antibody Pair (1091) (APMAB-1091LY)

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Target: SGTA
Specificity: Human
Datasheet SDS

SGTA Matched Antibody Pair (1090) (APMAB-1090LY)

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Target: SGTA
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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