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SGTA

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

Full Name

Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha

Function

Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892).
Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892).
Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373).
It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605).
Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484).
Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).

Biological Process

Negative regulation of ER-associated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ER-associated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Posttranslational protein targeting to endoplasmic reticulum membraneManual Assertion Based On ExperimentIBA:GO_Central
Tail-anchored membrane protein insertion into ER membraneManual Assertion Based On ExperimentIDA:UniProtKB
Ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis.

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Anti-SGTA antibodies

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Mouse Anti-SGTA Recombinant Antibody (CF394) (CBMAB-FT125LY)

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Target: SGTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CF394

Application*: ELISA, IF, WB, IHC

Mouse Anti-SGTA Recombinant Antibody (2E11) (CBMAB-A8072-LY)

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Target: SGTA

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2E11

Application*: WB, E

Rabbit Anti-SGTA (Phosphorylated S305) Recombinant Antibody (D23E10) (PTM-CBMAB-0581LY)

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Target: SGTA

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: D23E10

Application*: WB, IP

Mouse Anti-SGTA Recombinant Antibody (CBXS-3331) (CBMAB-S6068-CQ)

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Target: SGTA

Host: Mouse

Specificity: Mouse

Clone: CBXS-3331

Application*: E, WB

Mouse Anti-SGTA Recombinant Antibody (CBXS-2888) (CBMAB-S5637-CQ)

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Target: SGTA

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Rat

Clone: CBXS-2888

Application*: E, IF, IP, WB

Mouse Anti-SGTA Recombinant Antibody (CBXS-0337) (CBMAB-S3308-CQ)

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Target: SGTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-0337

Application*: WB

Mouse Anti-SGTA Recombinant Antibody (CBXS-5201) (CBMAB-S2418-CQ)

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Target: SGTA

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXS-5201

Application*: WB, E, IF

Mouse Anti-SGTA Recombinant Antibody (CBXS-4759) (CBMAB-S1988-CQ)

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Target: SGTA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBXS-4759

Application*: E, IF, IH, WB

Mouse Anti-SGTA Recombinant Antibody (CBXS-3784) (CBMAB-S1056-CQ)

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Target: SGTA

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-3784

Application*: WB, F, E, IF

SGTA Matched Antibody Pair (1091) (APMAB-1091LY)

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Target: SGTA

Specificity: Human

SGTA Matched Antibody Pair (1090) (APMAB-1090LY)

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Target: SGTA

Specificity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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