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Mouse Anti-SH2D3C Recombinant Antibody (2E3) (CBMAB-A8077-LY)

The product is antibody recognizes SH2D3C. The antibody 2E3 immunoassay techniques such as: WB, ELISA.
See all SH2D3C antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E3
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SH2D3C (NP_005480, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SH2 Domain Containing 3C
Entrez Gene ID
10044
UniProt ID
Q8N5H7
Alternative Names
CHAT; FLJ39664; NSP3; PRO34088
Function
Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139).
Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078).
Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139).
Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity).
Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity).
Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity).
Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity).
Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity).
Isoform 1
Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity).
Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity).
Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity).
May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity).
Isoform 2
May be involved in the BCAR1/CAS-mediated JNK activation pathway.
Biological Process
Biological Process JNK cascadeManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process small GTPase mediated signal transductionIEA:InterPro
Cellular Location
Cytoplasm
Cell membrane
Cell projection, axon
Cell projection, ruffle membrane
Associated with the membrane when EGF-stimulated (By similarity).
Expressed at the cortical actin ring in B cells (By similarity).
Isoform 1
Cell membrane
PTM
Isoform 1
Phosphorylated by MAPK/ERK upon T-cell receptor stimulation in T-cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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