SH2D3C

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Full Name
SH2 Domain Containing 3C
Function
Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139).
Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078).
Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139).
Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity).
Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity).
Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity).
Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity).
Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity).
Isoform 1
Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity).
Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity).
Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity).
May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity).
Isoform 2
May be involved in the BCAR1/CAS-mediated JNK activation pathway.
Biological Process
Biological Process JNK cascadeManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process small GTPase mediated signal transductionIEA:InterPro
Cellular Location
Cytoplasm
Cell membrane
Cell projection, axon
Cell projection, ruffle membrane
Associated with the membrane when EGF-stimulated (By similarity).
Expressed at the cortical actin ring in B cells (By similarity).
Isoform 1
Cell membrane
PTM
Isoform 1
Phosphorylated by MAPK/ERK upon T-cell receptor stimulation in T-cells.
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Anti-SH2D3C antibodies

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Mouse Anti-SH2D3C Recombinant Antibody (3F5) (CBMAB-A8083-LY)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F5
Application*: IF, E
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (3D6) (CBMAB-A8082-LY)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D6
Application*: WB, E
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (3C5) (CBMAB-A8081-LY)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C5
Application*: WB, E
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (2G1) (CBMAB-A8080-LY)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G1
Application*: WB, E
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (2B4) (CBMAB-A8079-LY)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B4
Application*: WB, E
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (1B6) (CBMAB-A8078-LY)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B6
Application*: WB, E
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (2E3) (CBMAB-A8077-LY)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E3
Application*: WB, E
Datasheet SDS

SH2D3C Matched Antibody Pair (1093) (APMAB-1093LY)

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Target: SH2D3C
Specificity: Human
Datasheet SDS

SH2D3C Matched Antibody Pair (1092) (APMAB-1092LY)

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Target: SH2D3C
Specificity: Human
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (CBXS-2930) (CBMAB-S5679-CQ)

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Target: SH2D3C
Host: Mouse
Specificity: Human
Clone: CBXS-2930
Application*: E, WB
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (CBXS-2845) (CBMAB-S5595-CQ)

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Target: SH2D3C
Host: Mouse
Specificity: Human
Clone: CBXS-2845
Application*: E, IF
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (CBXS-0341) (CBMAB-S3312-CQ)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0341
Application*: IF, SE, E, WB
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (CBXS-0340) (CBMAB-S3311-CQ)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0340
Application*: WB, E, WB
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (CBXS-4770) (CBMAB-S1997-CQ)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4770
Application*: E, P, WB
Datasheet SDS

Mouse Anti-SH2D3C Recombinant Antibody (CBXS-3883) (CBMAB-S1152-CQ)

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Target: SH2D3C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3883
Application*: E, IC, IF, WB
Datasheet SDS

Rabbit Anti-SH2D3C Recombinant Antibody (CBWJN-1674) (CBMAB-N4259-WJ)

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Target: SH2D3C
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1674
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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