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Mouse Anti-SH3GL2 Recombinant Antibody (2G6) (CBMAB-A8097-LY)

The product is antibody recognizes SH3GL2. The antibody 2G6 immunoassay techniques such as: WB, ELISA.
See all SH3GL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
2G6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SH3GL2 (NP_003017, 64 a.a. ~ 124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SH3-domain GRB2-like 2
Entrez Gene ID
Human6456
Rat116743
UniProt ID
HumanQ99962
RatO35179
Alternative Names
CNSA2; EEN-B1; FLJ20276; FLJ25015; SH3D2A; SH3P4
Function
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Biological Process
Biological Process cellular response to brain-derived neurotrophic factor stimulusISS:UniProtKB
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dendrite extensionISS:UniProtKB
Biological Process negative regulation of blood-brain barrier permeabilityManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process neuron projection developmentISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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