Rabbit Anti-SH3GL2 Recombinant Antibody (CBXS-1247) (CBMAB-S4106-CQ)

Name: Rabbit Anti-SH3GL2 Recombinant Antibody (CBXS-1247)
SKU: CBMAB-S4106-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1247

Application

WB, IP, IHC-P, IF

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SH3-domain GRB2-like 2

Introduction

SH3GL2 implicated in synaptic vesicle endocytosis and may recruit other proteins to membranes with high curvature. SH3GL2 required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.

Entrez Gene ID

Human	6456
Mouse	20404
Rat	116743

UniProt ID

Human	Q99962
Mouse	Q62420
Rat	O35179

Alternative Names

SH3 Domain Containing GRB2 Like 2, Endophilin A1; SH3 Domain-Containing GRB2-Like Protein 2; SH3 Domain Protein 2A; Endophilin-A1; Endophilin-1; EEN-B1; SH3D2A;

Function

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.

Biological Process

Biological Process cellular response to brain-derived neurotrophic factor stimulusISS:UniProtKB
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dendrite extensionISS:UniProtKB
Biological Process negative regulation of blood-brain barrier permeabilityManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process neuron projection developmentISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process synaptic vesicle uncoatingManual Assertion Based On ExperimentIBA:GO_Central

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-SH3GL2 Monoclonal Antibody (5A6) (CAT#: CBMAB-1149-YC)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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