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Mouse Anti-SHC3 Recombinant Antibody (CBWJN-1675) (CBMAB-N4260-WJ)

This product is a Mouse antibody that recognizes SHC3. The antibody CBWJN-1675 can be used for immunoassay techniques such as: WB, IF.
See all SHC3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJN-1675
Application
WB, IF

Basic Information

Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SHC (Src homology 2 domain containing) transforming protein 3
Introduction
SHC3 (SHC Adaptor Protein 3) is a Protein Coding gene. Diseases associated with SHC3 include Sarcomatous Intrahepatic Cholangiocarcinoma and Sclerosing Hepatic Carcinoma. Among its related pathways are Focal Adhesionand Endometrial cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.
Entrez Gene ID
Human25759
Mouse216148
Rat314612
UniProt ID
HumanP98077
MouseQ8BMC3
RatO70142
Alternative Names
SHC Adaptor Protein 3; SHC (Src Homology 2 Domain Containing) Transforming Protein 3; SHC-Transforming Protein C; SH2 Domain Protein C3; Neuronal Shc; Protein Rai; N-Shc; NSHC;
Function
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Biological Process
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intracellular signal transductionIEA:InterPro
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytosol
plasma membrane
PTM
Tyrosine phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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