Mouse Anti-SHMT1 Recombinant Antibody (CBXS-5076) (CBMAB-S2297-CQ)

Name: Mouse Anti-SHMT1 Recombinant Antibody (CBXS-5076)
SKU: CBMAB-S2297-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-5076

Application

ELISA, IHC-P, WB

Immunogen

Recombinant corresponding to aa374-483 from human SHMT1 with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Concentration

0.46 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Serine Hydroxymethyltransferase 1

Introduction

This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

6470

UniProt ID

P34896

Alternative Names

Serine Hydroxymethyltransferase 1; Cytoplasmic Serine Hydroxymethyltransferase; Serine Hydroxymethyltransferase 1 (Soluble); Glycine Hydroxymethyltransferase; Serine Methylase; EC 2.1.2.1;

Function

Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).

Biological Process

Biological Process cellular response to leukemia inhibitory factorManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to tetrahydrofolateManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process dTMP biosynthetic processIEA:Ensembl
Biological Process folic acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycine biosynthetic process from serineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glycine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-serine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-serine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of translationManual Assertion Based On ExperimentIDA:CAFA
Biological Process one-carbon metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein homotetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process purine nucleobase biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process tetrahydrofolate interconversionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process tetrahydrofolate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

SHMT1 Matched Antibody Pair (1094) (CAT#: APMAB-1094LY)

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SHMT1 Matched Antibody Pair (1094) (CAT#: APMAB-1094LY)

Mouse Anti-SHMT1 Recombinant Antibody (CBXS-4298) (CAT#: CBMAB-S1544-CQ)

Rabbit Anti-SHMT1 Recombinant Antibody (CBXS-0360) (CAT#: CBMAB-S3326-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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