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Mouse Anti-SHMT1 Recombinant Antibody (CBXS-5076) (CBMAB-S2297-CQ)

This product is a mouse antibody that recognizes SHMT1. The antibody CBXS-5076 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all SHMT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5076
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Recombinant corresponding to aa374-483 from human SHMT1 with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
0.46 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine Hydroxymethyltransferase 1
Introduction
This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
6470
UniProt ID
P34896
Alternative Names
Serine Hydroxymethyltransferase 1; Cytoplasmic Serine Hydroxymethyltransferase; Serine Hydroxymethyltransferase 1 (Soluble); Glycine Hydroxymethyltransferase; Serine Methylase; EC 2.1.2.1;
Function
Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).
Biological Process
Biological Process cellular response to leukemia inhibitory factorManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to tetrahydrofolateManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process dTMP biosynthetic processIEA:Ensembl
Biological Process folic acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycine biosynthetic process from serineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glycine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-serine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-serine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of translationManual Assertion Based On ExperimentIDA:CAFA
Biological Process one-carbon metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein homotetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process purine nucleobase biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process tetrahydrofolate interconversionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process tetrahydrofolate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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