SHMT1

This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Full Name

Serine Hydroxymethyltransferase 1

Function

Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).

Biological Process

Biological Process cellular response to leukemia inhibitory factorManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to tetrahydrofolateManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process dTMP biosynthetic processIEA:Ensembl
Biological Process folic acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycine biosynthetic process from serineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glycine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-serine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-serine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of translationManual Assertion Based On ExperimentIDA:CAFA
Biological Process one-carbon metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein homotetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process purine nucleobase biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process tetrahydrofolate interconversionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process tetrahydrofolate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm