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Mouse Anti-SHOC2 Recombinant Antibody (CBXS-2147) (CBMAB-S4911-CQ)

This product is a mouse antibody that recognizes SHOC2. The antibody CBXS-2147 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SHOC2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2147
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SHOC2, Leucine Rich Repeat Scaffold Protein
Introduction
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.
Entrez Gene ID
Human8036
Mouse56392
Rat309548
UniProt ID
HumanQ9UQ13
MouseO88520
RatQ6AYI5
Alternative Names
SHOC2, Leucine Rich Repeat Scaffold Protein; Soc-2 (Suppressor Of Clear, C.Elegans) Homolog; Soc-2 Suppressor Of Clear Homolog (C. Elegans); SHOC2 Leucine-Rich Repeat Scaffold Protein; Leucine-Rich Repeat Protein SHOC-2; Soc-2 Suppressor Of Clear Homolog; Protein Soc-2 Homolog;
Function
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Biological Process
Biological Process fibroblast growth factor receptor signaling pathway1 PublicationNAS:UniProtKB
Biological Process positive regulation of Ras protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transduction1 PublicationNAS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Translocates from cytoplasm to nucleus upon growth factor stimulation.
Involvement in disease
Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1):
A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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