Rabbit Anti-SHOC2 Recombinant Antibody (D7N1A) (CBMAB-CP2428-LY)

Name: Rabbit Anti-SHOC2 Recombinant Antibody (D7N1A)
SKU: CBMAB-CP2428-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

D7N1A

Application

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SHOC2 protein.

Specificity

Human, Mouse, Rat, Monkey, Chicken, Cattle, Dog

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

SHOC2, Leucine Rich Repeat Scaffold Protein

Introduction

This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]

Entrez Gene ID

Human	8036
Mouse	56392
Rat	309548
Monkey	695572
Cattle	511417
Dog	477819
Chicken	423894

UniProt ID

Human	Q9UQ13
Mouse	O88520
Rat	Q6AYI5
Monkey	F7HGG4
Chicken	Q5F4C4
Cattle	A6QLV3
Dog	A0A8I3PZC2

Alternative Names

SHOC2; Leucine Rich Repeat Scaffold Protein; Soc-2 (Suppressor Of Clear; C.Elegans) Homolog; Soc-2 Suppressor Of Clear Homolog (C. Elegans); SHOC2 Leucine-Rich Repeat Scaffold Protein; Leucine-Rich Repeat Protein SHOC-2; Soc-2 Suppressor Of Clear Homolog; Protein Soc-2 Homolog;

Function

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

Biological Process

Biological Process fibroblast growth factor receptor signaling pathway1 PublicationNAS:UniProtKB
Biological Process positive regulation of Ras protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Ras protein signal transduction1 PublicationNAS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Nucleus
Translocates from cytoplasm to nucleus upon growth factor stimulation.

Involvement in disease

Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1):
A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Rabbit Anti-SHOC2 Recombinant Antibody (CBXS-0361) (CAT#: CBMAB-S3327-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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