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Rabbit Anti-SHPK Recombinant Antibody (EG481) (CBMAB-EN545-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG481
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from N-terminal of human CARKL.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sedoheptulokinase
Introduction
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human23729
Mouse74637
Rat287479
UniProt ID
HumanQ9UHJ6
MouseQ9D5J6
RatQ3MID4
Alternative Names
Sedoheptulokinase; Carbohydrate Kinase-Like Protein; CARKL; SHK; Carbohydrate Kinase-Like; EC 2.7.1.14;
Function
Acts as a modulator of macrophage activation through control of glucose metabolism.
Biological Process
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to interleukin-13ISS:UniProtKB
Biological Process cellular response to interleukin-4ISS:UniProtKB
Biological Process cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycerol metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process pentose-phosphate shuntTAS:Reactome
Biological Process pentose-phosphate shunt, non-oxidative branchISS:UniProtKB
Biological Process phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseISS:UniProtKB
Biological Process regulation of macrophage activationISS:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Sedoheptulokinase deficiency (SHPKD):
An autosomal recessive metabolic disease characterized by increased urinary erythritol and sedoheptulose. Neonatal cholestasis, hypoglycemia, anemia, congenital arthrogryposis multiplex, multiple contractures and dysmorphisms have been reported in SHPKD patients, but the relationship of these features to the SHPKD is unclear.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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