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SHPK

The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
Full Name
Sedoheptulokinase
Function
Acts as a modulator of macrophage activation through control of glucose metabolism.
Biological Process
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to interleukin-13ISS:UniProtKB
Biological Process cellular response to interleukin-4ISS:UniProtKB
Biological Process cellular response to lipopolysaccharideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycerol metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process pentose-phosphate shuntTAS:Reactome
Biological Process pentose-phosphate shunt, non-oxidative branchISS:UniProtKB
Biological Process phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of inflammatory responseISS:UniProtKB
Biological Process regulation of macrophage activationISS:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Sedoheptulokinase deficiency (SHPKD):
An autosomal recessive metabolic disease characterized by increased urinary erythritol and sedoheptulose. Neonatal cholestasis, hypoglycemia, anemia, congenital arthrogryposis multiplex, multiple contractures and dysmorphisms have been reported in SHPKD patients, but the relationship of these features to the SHPKD is unclear.
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Anti-SHPK antibodies

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Mouse Anti-SHPK Recombinant Antibody (CBXS-5052) (CBMAB-S2273-CQ)

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Target: SHPK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5052
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SHPK Recombinant Antibody (CBXS-4853) (CBMAB-S2076-CQ)

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Target: SHPK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4853
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-SHPK Recombinant Antibody (CBXS-4341) (CBMAB-S1586-CQ)

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Target: SHPK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4341
Application*: F, WB
Datasheet SDS

Mouse Anti-SHPK Recombinant Antibody (CBXS-3976) (CBMAB-S1239-CQ)

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Target: SHPK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3976
Application*: IF, WB
Datasheet SDS

Mouse Anti-SHPK Recombinant Antibody (CBXS-3955) (CBMAB-S1218-CQ)

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Target: SHPK
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3955
Application*: F, WB
Datasheet SDS

Mouse Anti-SHPK Recombinant Antibody (CBXC-2844) (CBMAB-C5858-CQ)

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Target: SHPK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2844
Application*: WB, IH, IF, P
Datasheet SDS

Mouse Anti-SHPK Recombinant Antibody (3D7) (CBMAB-C5894-LY)

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Target: SHPK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D7
Application*: WB, P, IC/IF
Datasheet SDS

Rabbit Anti-SHPK Recombinant Antibody (EG481) (CBMAB-EN545-LY)

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Target: SHPK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG481
Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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