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Rabbit Anti-SIGLEC10 Recombinant Antibody (D4E3Z) (CBMAB-CP2434-LY)

The product is antibody recognizes SIGLEC10. The antibody D4E3Z immunoassay techniques such as: WB,IP.
See all SIGLEC10 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
D4E3Z
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro250 of mouse Siglec-10 protein.
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
sialic acid binding Ig like lectin 10
Introduction
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
Entrez Gene ID
243958
UniProt ID
Q80ZE3
Alternative Names
PRO940; SIGLEC-10; SLG2
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity).
The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025).
Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity).
In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity).
In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598).
Plays a role in the control of autoimmunity (By similarity).
During initiation of adaptive immune responses by CD8-alpha+ dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process negative regulation of inflammatory response to woundingManual Assertion Based On ExperimentIPI:UniProtKB
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Cell membrane
Isoform 3
Cell membrane
Isoform 4
Cell membrane
Isoform 5
Secreted
Topology
Extracellular: 17-550
Helical: 551-571
Cytoplasmic: 572-697
PTM
Phosphorylation of Tyr-667 is involved in binding to PTPN6.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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