SIGLEC10

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

Full Name

sialic acid binding Ig like lectin 10

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity).
The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738, PubMed:12163025).
Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity).
In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity).
In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598).
Plays a role in the control of autoimmunity (By similarity).
During initiation of adaptive immune responses by CD8-alpha+ dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process negative regulation of inflammatory response to woundingManual Assertion Based On ExperimentIPI:UniProtKB

Cellular Location

Isoform 1
Cell membrane
Isoform 2
Cell membrane
Isoform 3
Cell membrane
Isoform 4
Cell membrane
Isoform 5
Secreted

Topology

Extracellular: 17-550
Helical: 551-571
Cytoplasmic: 572-697

PTM

Phosphorylation of Tyr-667 is involved in binding to PTPN6.