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Mouse Anti-SIM2 Recombinant Antibody (3E6) (CBMAB-A8130-LY)

The product is antibody recognizes SIM2. The antibody 3E6 immunoassay techniques such as: WB, ELISA.
See all SIM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SIM2 (NP_005060, 426 a.a. ~ 525 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
single-minded homolog 2 (Drosophila)
Introduction
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes [provided by RefSeq]
Entrez Gene ID
6493
UniProt ID
Q14190
Alternative Names
MGC119447; SIM; bHLHe15
Function
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process embryonic pattern specificationIEA:Ensembl
Biological Process lung developmentIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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