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Mouse Anti-SIM2 Recombinant Antibody (CBXS-4873) (CBMAB-S2096-CQ)

This product is a mouse antibody that recognizes SIM2. The antibody CBXS-4873 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all SIM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4873
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
single-minded homolog 2 (Drosophila)
Introduction
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
6493
UniProt ID
Q14190
Alternative Names
Single-Minded Family BHLH Transcription Factor 2; Class E Basic Helix-Loop-Helix Protein 15; Transcription Factor SIM2; BHLHe15; Single-Minded (Drosophila) Homolog 2; Single-Minded Homolog 2 (Drosophila);
Function
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process embryonic pattern specificationIEA:Ensembl
Biological Process lung developmentIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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