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SIM2

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes [provided by RefSeq]
Full Name
single-minded homolog 2 (Drosophila)
Function
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process embryonic pattern specificationIEA:Ensembl
Biological Process lung developmentIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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Anti-SIM2 antibodies

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Mouse Anti-SIM2 Recombinant Antibody (3E6) (CBMAB-A8130-LY)

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Target: SIM2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E6
Application*: WB, E
Datasheet SDS

Rabbit Anti-SIM2 Recombinant Antibody (CBXS-1584) (CBMAB-S4433-CQ)

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Target: SIM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1584
Application*: WB
Datasheet SDS

Mouse Anti-SIM2 (AA 426-526) Recombinant Antibody (CBXS-0376) (CBMAB-S3338-CQ)

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Target: SIM2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0376
Application*: E, WB
Datasheet SDS

Mouse Anti-SIM2 Recombinant Antibody (CBXS-4873) (CBMAB-S2096-CQ)

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Target: SIM2
Host: Mouse
Specificity: Human
Clone: CBXS-4873
Application*: WB, IP, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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