Mouse Anti-SIPA1 Recombinant Antibody (331-9) (CBMAB-S2842-CQ)

Name: Mouse Anti-SIPA1 Recombinant Antibody (331-9)
SKU: CBMAB-S2842-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

331-9

Application

IHC-P, IP, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 50% glycerol

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Signal-Induced Proliferation-Associated 1

Introduction

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.

Entrez Gene ID

6494

UniProt ID

Q96FS4

Alternative Names

Signal-Induced Proliferation-Associated 1; GTPase-Activating Protein Spa-1; P130 SPA-1; Sipa-1; SPA1; Signal-Induced Proliferation-Associated Protein 1; Signal-Induced Proliferation-Associated Gene 1;

Function

GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962).
Affects cell cycle progression (By similarity).

Biological Process

Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adaptive immune responseTAS:Reactome
Biological Process cellular response to water deprivationIEA:Ensembl
Biological Process cytoskeleton organization1 PublicationNAS:UniProtKB
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell adhesion1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell cycle1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Cytoplasm, perinuclear region
Endomembrane system
Mostly localized in the perinuclear membraneous region.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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