SIPA1

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.

Signal-Induced Proliferation-Associated 1

GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962).
Affects cell cycle progression (By similarity).

Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adaptive immune responseTAS:Reactome
Biological Process cellular response to water deprivationIEA:Ensembl
Biological Process cytoskeleton organization1 PublicationNAS:UniProtKB
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell adhesion1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell cycle1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Nucleus
Cytoplasm, perinuclear region
Endomembrane system
Mostly localized in the perinuclear membraneous region.