SIPA1

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Full Name
Signal-Induced Proliferation-Associated 1
Function
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962).
Affects cell cycle progression (By similarity).
Biological Process
Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adaptive immune responseTAS:Reactome
Biological Process cellular response to water deprivationIEA:Ensembl
Biological Process cytoskeleton organization1 PublicationNAS:UniProtKB
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell adhesion1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell cycle1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm, perinuclear region
Endomembrane system
Mostly localized in the perinuclear membraneous region.
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Anti-SIPA1 antibodies

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Rabbit Anti-SIPA1 Recombinant Antibody (CBXS-1372) (CBMAB-S4230-CQ)

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Target: SIPA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBXS-1372
Application*: WB, P, F, IF
Datasheet SDS

Mouse Anti-SIPA1 Recombinant Antibody (331-9) (CBMAB-S2842-CQ)

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Target: SIPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 331-9
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-SIPA1 Recombinant Antibody (CBXS-4723) (CBMAB-S1953-CQ)

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Target: SIPA1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXS-4723
Application*: IP, WB
Datasheet SDS

Mouse Anti-SIPA1 Recombinant Antibody (CBXS-4395) (CBMAB-S1638-CQ)

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Target: SIPA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4395
Application*: E
Datasheet SDS

Rat Anti-SIPA1 Recombinant Antibody (CBXS-4274) (CBMAB-S1522-CQ)

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Target: SIPA1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXS-4274
Application*: IP, WB
Datasheet SDS

Human SIPA1 ELISA Kit (V2LY-0626-LY4239)

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Target: SIPA1
Sensitivity: 0.0042 ng/mL
Detection Range: 0.007-1.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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