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Rat Anti-SIPA1 Recombinant Antibody (CBXS-4274) (CBMAB-S1522-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXS-4274
Antibody Isotype
IgG2a, κ
Application
IP, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 50% glycerol
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Signal-Induced Proliferation-Associated 1
Introduction
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Entrez Gene ID
20469
UniProt ID
Q3V403
Alternative Names
Spa1
Function
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962).
Affects cell cycle progression (By similarity).
Biological Process
Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process adaptive immune responseTAS:Reactome
Biological Process cellular response to water deprivationIEA:Ensembl
Biological Process cytoskeleton organization1 PublicationNAS:UniProtKB
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell adhesion1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell cycle1 PublicationNAS:UniProtKB
Biological Process negative regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm, perinuclear region
Endomembrane system
Mostly localized in the perinuclear membraneous region.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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