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Mouse Anti-SIRT3 Recombinant Antibody (CBT2394) (V2LY-0625-LY386)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2394
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant fragment of human SIRT3 (AA: 155-290) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SIRT3
Entrez Gene ID
23410
Function
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340).
Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090).
Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340).
Contributes to the regulation of the cellular energy metabolism (PubMed:24252090).
Important for regulating tissue-specific ATP levels (PubMed:18794531).
In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).
Biological Process
Biological Process aerobic respirationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine deacetylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of catalase activityManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of ceramide biosynthetic processISS:UniProtKB
Biological Process positive regulation of superoxide dismutase activityManual Assertion Based On ExperimentIDA:CACAO
Biological Process protein ADP-ribosylationBy SimilarityISS:GO_Central
Biological Process protein deacetylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion matrix
PTM
Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.
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For research use only. Not intended for any clinical use.

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