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Human Anti-SIT1 Recombinant Antibody (CBXS-3574) (CBMAB-S0389-CQ)

This product is a human antibody that recognizes SIT1. The antibody CBXS-3574 can be used for immunoassay techniques such as: FC.
See all SIT1 antibodies

Summary

Host Animal
Human
Specificity
Human
Clone
CBXS-3574
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Signaling Threshold Regulating Transmembrane Adaptor 1
Entrez Gene ID
27240
UniProt ID
Q9Y3P8
Alternative Names
Signaling Threshold Regulating Transmembrane Adaptor 1; SHP2-Interacting Transmembrane Adapter Protein; Suppression Inducing Transmembrane Adaptor 1; Suppression-Inducing Transmembrane Adapter 1; SHP2 Interacting Transmembrane Adaptor; Gp30/40;
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process regulation of T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process T cell homeostasisIEA:InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 25-40
Helical: 41-61
Cytoplasmic: 62-196
PTM
Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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