Human Anti-SIT1 Recombinant Antibody (CBXS-3574) (CBMAB-S0389-CQ)

Name: Human Anti-SIT1 Recombinant Antibody (CBXS-3574)
SKU: CBMAB-S0389-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Human

Clone

CBXS-3574

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Signaling Threshold Regulating Transmembrane Adaptor 1

Entrez Gene ID

27240

UniProt ID

Q9Y3P8

Alternative Names

Signaling Threshold Regulating Transmembrane Adaptor 1; SHP2-Interacting Transmembrane Adapter Protein; Suppression Inducing Transmembrane Adaptor 1; Suppression-Inducing Transmembrane Adapter 1; SHP2 Interacting Transmembrane Adaptor; Gp30/40;

Function

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process regulation of T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process T cell homeostasisIEA:InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 25-40
Helical: 41-61
Cytoplasmic: 62-196

PTM

Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SIT1 Recombinant Antibody (SIT-01) (CAT#: CBMAB-S0177-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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