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SIT1

Full Name

Signaling Threshold Regulating Transmembrane Adaptor 1

Function

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.

Biological Process

Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process regulation of T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process T cell homeostasisIEA:InterPro

Cellular Location

Cell membrane

Topology

Extracellular: 25-40
Helical: 41-61
Cytoplasmic: 62-196

PTM

Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK.

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Anti-SIT1 antibodies

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Human Anti-SIT1 Recombinant Antibody (CBXS-3574) (CBMAB-S0389-CQ)

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Target: SIT1

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3574

Application*: F

Mouse Anti-SIT1 Recombinant Antibody (SIT-01) (CBMAB-S0177-CQ)

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Target: SIT1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: SIT-01

Application*: F, IH, IP, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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