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Mouse Anti-SIT1 Recombinant Antibody (SIT-01) (CBMAB-S0177-CQ)

This product is a mouse antibody that recognizes SIT1. The antibody SIT-01 can be used for immunoassay techniques such as: FC, IHC, IP, WB.
See all SIT1 antibodies
Published Data
Fig.1 Immunostaining of normal hematopoietic tissue and appendix for the T- and B-cell–associated transmembrane adaptor proteins.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
SIT-01
Antibody Isotype
IgG1
Application
FC, IHC, IP, WB

Basic Information

Immunogen
Bacterially produced recombinant intracellular fragment of human SIT
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
15 mM sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Signaling Threshold Regulating Transmembrane Adaptor 1
Entrez Gene ID
27240
UniProt ID
Q9Y3P8
Alternative Names
Signaling Threshold Regulating Transmembrane Adaptor 1; SHP2-Interacting Transmembrane Adapter Protein; Suppression Inducing Transmembrane Adaptor 1; Suppression-Inducing Transmembrane Adapter 1; SHP2 Interacting Transmembrane Adaptor; Gp30/40;
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process regulation of T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process T cell homeostasisIEA:InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 25-40
Helical: 41-61
Cytoplasmic: 62-196
PTM
Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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